Xgeva 120 mg Injection (Denosumab) is a monoclonal antibody used to prevent bone fractures and complications in adults with bone metastases from solid tumors (e.g., breast, prostate, lung cancer), and to treat giant cell tumor of bone that is unresectable. It works by inhibiting the RANK ligand (RANKL), reducing bone resorption and helping maintain bone integrity.

Each pre-filled syringe contains 120 mg Denosumab in 1 mL for subcutaneous injection. Doctors recommend administering one injection every 4 weeks, typically alongside calcium and vitamin D supplements to support bone health.

Common side effects include low calcium levels (hypocalcemia), musculoskeletal pain, and mild skin reactions. Rare but serious effects include osteonecrosis of the jaw (ONJ) and atypical femur fractures—dental check-ups and calcium monitoring before and during treatment are essential.

Store Xgeva syringes in the refrigerator at 2 °C to 8 °C. Do not freeze. Keep syringes in the original carton to protect them from light.